Heparin sodium
Calciparine, Defencath, Embolex, Heparin (heparin sodium) is an oligosaccharide pharmaceutical. Heparin sodium was first approved as Calciparine on 1982-01-01. It is used to treat cerebral infarction, coronary thrombosis, myocardial infarction, postoperative complications, and pulmonary embolism amongst others in the USA. The pharmaceutical is active against antithrombin-III.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Heparin
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| defencath | New Drug Application | 2024-12-23 |
| heparin | unapproved drug other | 2012-08-09 |
| heparin sodium | unapproved drug other | 2014-12-24 |
| heparin sodium | New Drug Application | 2025-08-21 |
| heparin sodium and dextrose | New Drug Application | 2025-07-01 |
| heparin sodium and sodium chloride | New Drug Application | 2019-04-19 |
| heparin sodium in dextrose | New Drug Application | 2023-07-31 |
| heparin sodium in sodium chloride | New Drug Application | 2025-08-06 |
Indications
FDA
EMA
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
HEPARIN SODIUM / TAUROLIDINE, DEFENCATH, CORMEDIX | |||
| 2033-11-15 | GAIN | ||
| 2028-11-15 | NCE | ||
ATC Codes
B: Blood and blood forming organ drugs
— B01: Antithrombotic agents
— B01A: Antithrombotic agents
— B01AB: Heparin group antithrombotic drugs
— B01AB01: Heparin
— B01AB51: Heparin, combinations
— B01AC: Platelet aggregation inhibitors excl. heparin
— B01AC30: Platelet aggregation inhibitor combinations excl. heparin
C: Cardiovascular system drugs
— C05: Vasoprotectives
— C05B: Antivaricose therapy drugs
— C05BA: Heparins or heparinoids for topical use
— C05BA03: Heparin
— C05BA53: Heparin, combinations
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01X: Other ophthalmologicals in atc
— S01XA: Other ophthalmologicals in atc
— S01XA14: Heparin
Clinical
Clinical Trials
1686 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Thrombosis | D013927 | — | — | 12 | 36 | 60 | 49 | 97 | 240 |
| Thromboembolism | D013923 | — | — | 8 | 41 | 78 | 39 | 69 | 224 |
| Venous thromboembolism | D054556 | EFO_0004286 | I74 | 8 | 37 | 72 | 29 | 65 | 201 |
| Venous thrombosis | D020246 | — | I82.40 | 7 | 28 | 47 | 37 | 58 | 168 |
| Covid-19 | D000086382 | — | U07.1 | 6 | 27 | 35 | 14 | 39 | 107 |
| Pulmonary embolism | D011655 | EFO_0003827 | I26 | 9 | 10 | 33 | 24 | 26 | 97 |
| Embolism | D004617 | — | — | 8 | 8 | 27 | 19 | 24 | 81 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | 4 | 18 | 23 | 25 | 69 |
| Hemorrhage | D006470 | MP_0001914 | R58 | 1 | 6 | 12 | 14 | 25 | 57 |
| Infarction | D007238 | EFO_0009463 | — | — | 4 | 10 | 17 | 26 | 56 |
Show 181 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 16 | 3 | 1 | — | 5 | 23 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | 2 | 5 | — | 14 | 21 |
| Septic shock | D012772 | — | A48.3 | 1 | 3 | 2 | — | 14 | 20 |
| Multiple myeloma | D009101 | — | C90.0 | 3 | 4 | 2 | — | 4 | 12 |
| Pain | D010146 | EFO_0003843 | R52 | — | 1 | 2 | — | 10 | 12 |
| Cystitis | D003556 | EFO_1000025 | N30 | — | 8 | 1 | — | 1 | 10 |
| Newborn respiratory distress syndrome | D012127 | — | P22 | 2 | 4 | 2 | — | 5 | 10 |
| Replacement arthroplasty knee | D019645 | — | — | — | 5 | 3 | — | 1 | 9 |
| Plasma cell neoplasms | D054219 | — | — | 3 | 3 | 1 | — | 3 | 9 |
| Pre-eclampsia | D011225 | EFO_0000668 | O14 | — | 1 | 4 | — | 4 | 8 |
Show 106 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cholangiocarcinoma | D018281 | — | C22.1 | 1 | 4 | — | — | 1 | 6 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | — | 4 | — | — | 2 | 6 |
| Coronary stenosis | D023921 | EFO_1000882 | — | — | 1 | — | — | 4 | 5 |
| Renal cell carcinoma | D002292 | EFO_0000376 | — | 2 | 1 | — | — | 2 | 4 |
| Carotid artery diseases | D002340 | EFO_0003781 | — | — | 1 | — | — | 3 | 4 |
| Myeloid leukemia | D007951 | — | C92 | 3 | 1 | — | — | — | 4 |
| Systemic inflammatory response syndrome | D018746 | EFO_1001478 | R65.10 | — | 1 | — | — | 3 | 4 |
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | 1 | 2 | — | — | 1 | 3 |
| B-cell lymphoma | D016393 | — | — | 2 | 2 | — | — | — | 3 |
| Kidney neoplasms | D007680 | EFO_0003865 | C64 | 1 | 1 | — | — | 2 | 3 |
Show 69 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Blood platelet disorders | D001791 | — | — | 1 | — | — | — | 3 | 4 |
| Blood pressure | D001794 | EFO_0004325 | — | 2 | — | — | — | 1 | 3 |
| Congenital heart defects | D006330 | — | Q24.9 | 1 | — | — | — | 2 | 3 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 1 | — | — | — | 1 | 2 |
| Hodgkin disease | D006689 | — | C81 | 1 | — | — | — | 1 | 2 |
| Congenital abnormalities | D000013 | EFO_0003915 | Q89.9 | 1 | — | — | — | 1 | 2 |
| Systemic lupus erythematosus | D008180 | EFO_0002690 | M32 | 1 | — | — | — | 1 | 2 |
| Neuroblastoma | D009447 | EFO_0000621 | — | 1 | — | — | — | 1 | 2 |
| Hearing loss | D034381 | EFO_0004238 | H91.9 | 1 | — | — | — | 1 | 2 |
| Sensorineural hearing loss | D006319 | — | H90.5 | 1 | — | — | — | 1 | 2 |
Show 24 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Postoperative complications | D011183 | — | — | — | — | — | — | 6 | 6 |
| Carotid stenosis | D016893 | — | — | — | — | — | — | 6 | 6 |
| Chest pain | D002637 | — | R07.9 | — | — | — | — | 5 | 5 |
| Pathologic constriction | D003251 | — | — | — | — | — | — | 5 | 5 |
| Non-alcoholic fatty liver disease | D065626 | EFO_0003095 | K75.81 | — | — | — | — | 4 | 4 |
| Post-acute covid-19 syndrome | D000094024 | — | — | — | — | — | — | 4 | 4 |
| Cytokine release syndrome | D000080424 | — | D89.83 | — | — | — | — | 3 | 3 |
| Blood coagulation | D001777 | GO_0007596 | — | — | — | — | — | 3 | 3 |
| Esophageal and gastric varices | D004932 | EFO_0009545 | I85 | — | — | — | — | 3 | 3 |
| Fatty liver | D005234 | EFO_0003934 | — | — | — | — | — | 3 | 3 |
Show 223 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Heparin sodium |
| INN | heparin sodium |
| Description | Heparin, also known as unfractionated heparin (UFH), is a medication and naturally occurring glycosaminoglycan. Heparin is a blood anticoagulant that increases the activity of antithrombin. It is used in the treatment of heart attacks and unstable angina. It can be given intravenously or by injection under the skin. Its anticoagulant properties make it useful to prevent blood clotting in blood specimen test tubes and kidney dialysis machines.
|
| Classification | Oligosaccharide |
| Drug class | heparin derivatives and low molecular weight (or depolymerized) heparins |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | 9005-49-6 |
| RxCUI | 5224 |
| ChEMBL ID | CHEMBL1201657 |
| ChEBI ID | — |
| PubChem CID | 22833565 |
| DrugBank | DB01109 |
| UNII ID | ZZ45AB24CA (ChemIDplus, GSRS) |
Target
Agency Approved
SERPINC1
SERPINC1
Organism
Homo sapiens
Gene name
SERPINC1
Gene synonyms
AT3
NCBI Gene ID
Protein name
antithrombin-III
Protein synonyms
serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1, Serpin C1, serpin peptidase inhibitor clade C member 1, serpin peptidase inhibitor, clade C (antithrombin), member 1
Uniprot ID
Mouse ortholog
Serpinc1 (11905)
antithrombin-III (P32261)
Alternate
No data
Variants
No data
Financial
No data
Trends
PubMed Central
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Safety
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Adverse Events
Top Adverse Reactions
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20,567 adverse events reported
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